Reverse thermo-responsive hydrogels prepared from Pluronic F127 and gelatin composite materials

Composite Materials of Thermo-responsive Polymer Networks and Inorganic Nanoparticles

The focus of this work is on composite materials of inorganic nanoparticles such as TiO2 embedded within microspheres of a responsive polymeric network. Microgels of N-isopropylacrylamide (NIPAM) with interpenetrating (IP) linear chains of poly(acrylic acid) (PAAc) were synthesized to promote the incorporation of TiO2. Dynamic light scattering measurements of the IP-microgels in aqueous environ...

Mechanically Tough Pluronic F127/Laponite Nanocomposite Hydrogels from Covalently and Physically Cross-Linked Networks

Temperature-responsive and degradable hyaluronic acid/Pluronic composite hydrogels for controlled release of human growth hormone.

Temperature-sensitive hyaluronic acid (HA) hydrogels were synthesized by photopolymerization of vinyl group modified HA in combination with acrylate group end-capped poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) tri-block copolymer (Pluronic F127). The synthesized HA/Pluronic composite hydrogels gradually collapsed with increasing temperature over the range of 5-40 degrees ...

Physicochemical characterization and drug release of thermosensitive hydrogels composed of a hyaluronic acid/pluronic f127 graft.

Pluronic F127 (PF127) is a copolymer which forms thermosensitive hydrogels. Hyaluronic acid (HA) was grafted to PF127 to form a new hydrogel matrix (HP) for delivery of cisplatin and carboplatin. The physicochemical properties and drug delivery of the graft were examined in this study. HP system (20% HP copolymer in water) exhibited a similar sol-gel transition temperature (28.3 degrees C) as P...

Synthesis and Characterization of Biodegradable Thermo- and pH-Sensitive Hydrogels Based on Pluronic F127/Poly(ε-caprolactone) Macromer and Acrylic Acid

Several kinds of biodegradable hydrogels were prepared via in situ photopolymerization of Pluronic F127/poly(ε-caprolactone) macromer and acrylic acid (AA) comonomer in aqueous medium. The swelling kinetics measurements showed that the resultant hydrogels exhibited both thermoand pH-sensitive behaviors, and that this stimuli-responsiveness underwent a fast reversible process. With increasing pH...